Molecular Dimensions MD1-46 Morpheus 96 x 10 ml

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A 96 condition protein crystallization screen with original chemistry incorporating a range of low molecular weight ligands found ordered in more than 33000 PDB structures. Developed and utilized in the world-renowned Laboratory of Molecular Biology, (Cambridge, UK) – Morpheus® carries on the tradition of being original and dynamic. This unique screen aims to unlock novel chemical space previously inaccessible using conventional screens.

96 条件蛋白质结晶筛选与原始化学结合发现在超过 33000 个 PDB 结构中发现的一系列低分子量配体。 在世界著名的分子生物学实验室（英国剑桥）开发和使用 – Morpheus® 继承了原创和动态的传统。 这种独特的屏幕旨在解锁以前使用传统屏幕无法进入的新型化学空间。

An IUCr Webinar describing the formulation of the Morpheus® screens is available hereMolecular Dimensions, as well as a webinar describing the four-corner method for optimizing crystals obtained in Morpheus® conditions. The kit is presented as a 96 condition screen.

Features of Morpheus®:

• Simple and effective 3D grid design covering a range of pH, PEGs and salt additives.
• 49 low molecular weight ligands promote both initial crystal formation and lattice stability.
• Ideal for membrane proteins (contains PEGS and low salt)
• Reduced crystal “stress” – all conditions are cryo-protected.
• Derived from extensive data mining of over 33,000 PDB entries.
• Available in both 10 mL tube and 96 condition deep well block formats.

This product has been designed and developed by Fabrice Gorrec, in collaboration with the scientists at the Medical Research Council Laboratory of Molecular Biology (LMB) at Cambridge and is manufactured exclusively under license by Molecular Dimensions Limited.

References  参考文献

Witek, W., Sliwiak, J. & Ruszkowski, M. Structural and mechanistic insights into the bifunctional HISN2 enzyme catalyzing the second and third steps of histidine biosynthesis in plants. Sci Rep 11: 9647 (2021)

Kozak, S et al. Homogeneously N-glycosylated proteins derived from the GlycoDelete HEK293 cell line enable diffraction-quality crystallogenesis D76: 1244-1255 (2020)

Gorrec, F., & Löwe, J. Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology 131: 55790 (2018)

Sonani, Ravi R et al. An improved crystal structure of C-phycoerythrin from the marine cyanobacterium Phormidium sp. A09DM. 135(1): 65-78 (2018)

Gorrec, F. Protein crystallization screens developed at the MRC Laboratory of Molecular Biology 21(5): 819-825 (2016)
Gorrec, F. The MORPHEUS protein crystallization screen. Journal Applied Crystallography 42: 1035-42 (2009)